Thomas G Beach Selected Research

Amyloid Plaque

1/2022	A History of Senile Plaques: From Alzheimer to Amyloid Imaging.
10/2021	Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.
1/2021	Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies.
1/2021	Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau.
1/2021	Vascular Lesions, APOE ε4, and Tau Pathology in Alzheimer Disease.
1/2021	Clinicopathological Correlation: Dopamine and Amyloid PET Imaging with Neuropathology in Three Subjects Clinically Diagnosed with Alzheimer's Disease or Dementia with Lewy Bodies.
1/2020	Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
11/2019	Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia.
10/2018	Estimation of amyloid distribution by [18F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition.
1/2018	Antemortem-Postmortem Correlation of Florbetapir (18F) PET Amyloid Imaging with Quantitative Biochemical Measures of Aβ42 but not Aβ40.

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Thomas G Beach Research Topics

Disease

114	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 11/2002
57	Dementia (Dementias) 01/2022 - 11/2002
47	Parkinson Disease (Parkinson's Disease) 01/2021 - 07/2009
41	Amyloid Plaque 01/2022 - 11/2002
19	Cognitive Dysfunction 01/2022 - 12/2006
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2011
18	Synucleinopathies 01/2022 - 11/2012
16	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2019 - 10/2006
11	Frontotemporal Dementia (Semantic Dementia) 10/2021 - 10/2006
10	Lewy Body Disease (Lewy Body Dementia) 01/2021 - 06/2010
8	Tauopathies 01/2022 - 07/2003
8	Death (Near-Death Experience) 06/2020 - 11/2011
7	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2022 - 03/2003
7	Inflammation (Inflammations) 01/2020 - 02/2002
6	Disease Progression 11/2019 - 04/2006
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2014 - 07/2008
5	COVID-19 01/2022 - 01/2021
5	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2019 - 11/2008
4	Parkinsonian Disorders (Parkinsonism) 01/2021 - 01/2018
4	Corticobasal Degeneration 01/2019 - 11/2008
4	Deglutition Disorders (Dysphagia) 08/2015 - 06/2012
4	Hippocampal Sclerosis 01/2014 - 12/2010
3	Neoplasms (Cancer) 07/2017 - 01/2012
2	Carotid Artery Diseases 01/2022 - 01/2019
2	Cardiovascular Diseases (Cardiovascular Disease) 10/2021 - 01/2012
2	Neuroinflammatory Diseases 09/2021 - 01/2019
2	Encephalitis (Encephalitis, Rasmussen) 02/2021 - 01/2017
2	Pneumonia (Pneumonitis) 01/2021 - 02/2013
2	Heart Failure 01/2021 - 01/2011
2	REM Sleep Behavior Disorder 01/2021 - 07/2017
2	Intracranial Arteriosclerosis (Cerebral Atherosclerosis) 01/2021 - 01/2007
2	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2021 - 01/2018
2	Amyloidosis 01/2020 - 10/2015
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2016
2	Ganglion Cysts (Ganglion) 10/2018 - 01/2018
2	Memory Disorders (Memory Loss) 01/2017 - 10/2007
2	TDP-43 Proteinopathies 01/2017 - 11/2008
2	Atrophy 12/2016 - 12/2014
2	Stroke (Strokes) 01/2016 - 01/2011

Drug/Important Bio-Agent (IBA)

61	Amyloid (Amyloid Fibrils)IBA 01/2022 - 03/2003
40	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2006
27	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2009
27	SynucleinsIBA 01/2022 - 07/2011
19	Peptides (Polypeptides)IBA 01/2021 - 11/2002
14	alpha-SynucleinIBA 01/2021 - 06/2010
13	Amyloid beta-PeptidesIBA 01/2022 - 11/2002
12	Apolipoproteins E (ApoE)IBA 01/2022 - 04/2007
11	ProgranulinsIBA 10/2021 - 10/2006
11	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 10/2007
9	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2016
7	florbetapirIBA 01/2021 - 01/2011
7	flutemetamolIBA 11/2019 - 03/2015
7	ApolipoproteinsIBA 10/2015 - 01/2007
5	AntibodiesIBA 01/2022 - 07/2008
5	Messenger RNA (mRNA)IBA 01/2022 - 03/2009
5	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 08/2013
4	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2012
4	CytokinesIBA 01/2022 - 01/2015
4	ProteomeIBA 01/2021 - 01/2019
4	Protein Isoforms (Isoforms)IBA 01/2020 - 11/2008
4	sarkosylIBA 01/2017 - 07/2008
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2014 - 09/2007
4	UbiquitinIBA 11/2008 - 10/2006
3	ORALIT (ORS)IBA 01/2021 - 01/2007
3	Apolipoprotein E4IBA 01/2021 - 10/2015
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 01/2013
3	Retinaldehyde (Retinal)IBA 11/2020 - 06/2014
3	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2020 - 08/2013
3	MicroRNAs (MicroRNA)IBA 11/2017 - 01/2016
3	Pharmaceutical PreparationsIBA 07/2017 - 02/2013
3	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2017 - 05/2014
3	Glucose (Dextrose)FDA LinkGeneric 02/2015 - 03/2008
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2013 - 11/2008
3	Cholinergic Agents (Cholinergics)IBA 07/2011 - 04/2006
3	Coloring Agents (Dyes)IBA 01/2011 - 08/2008
2	Threonine (L-Threonine)FDA Link 01/2022 - 02/2015
2	GranulinsIBA 10/2021 - 01/2017
2	lysosomal proteinsIBA 10/2021 - 12/2019
2	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 01/2021 - 11/2017
2	Serine (L-Serine)FDA Link 01/2021 - 06/2014
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 06/2020 - 01/2020
2	LipidsIBA 09/2019 - 01/2019
2	Sirtuin 3IBA 01/2019 - 11/2018
2	Formaldehyde (Formol)FDA Link 01/2019 - 03/2014
2	ParaffinIBA 01/2019 - 03/2014
2	tau Proteins (tau Protein)IBA 11/2018 - 01/2017
2	Neuroprotective AgentsIBA 11/2018 - 01/2018
2	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2018 - 10/2016
2	Leucine (L-Leucine)FDA Link 01/2018 - 07/2013
2	ChemokinesIBA 01/2016 - 01/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 01/2012
2	Phosphotransferases (Kinase)IBA 07/2013 - 01/2013
2	PresenilinsIBA 01/2013 - 11/2008
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2013 - 11/2008
2	thioflavin TIBA 01/2012 - 08/2008

Therapy/Procedure

13	Therapeutics 10/2021 - 11/2002
4	Immunotherapy 01/2016 - 08/2008
2	Denervation 01/2020 - 08/2013
2	Aftercare (After-Treatment) 01/2018 - 01/2011
2	Deep Brain Stimulation 01/2018 - 01/2017